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When psychologist Martin Seligman became president of the American Psychological Association (APA) in 1998, he did something radical. Over the years, he had grown tired of his fields’ constant focus on the negative (mental illness, trauma, suffering, pain) and felt that more attention should be paid to the other side of the coin: happiness, well-being, and flourishing. He called this “positive psychology,” and made it the theme of his one-year term as APA’s leader. Instead of focusing solely on reducing ill-being, Seligman organized researchers and practitioners around the idea that people should also be given the tools to thrive. According to experts, psychedelics could be on the way to becoming one of those tools. The past few years have brought a renaissance of research into the role of LSD, psilocybin (aka “magic mushrooms”), MDMA, ayahuasca, and other psychedelic substances in treating depression, PTSD, addiction, and other forms of mental illness. Now, there is a growing interest in bringing the purported benefits of these drugs to “healthy” people — those without diagnosed mental health disorders — in order to help them attain more aspirational levels of well-being.

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OK, but does access to this altered state of mind brought on by a psychedelic trip really lead to increased wellness in healthy people? It depends on who you ask, and what “wellness” means to them, which makes the debate around psychedelics for healthy people a complicated one without definitive boundaries. Whereas the presence or absence of depression can be measured on a clinical, APA-approved scale, things like “betterment” and “self-improvement” in healthy people are subjective experiences that are hard to quantify. Wellness in this country is still measured against an absence of disorder rather than markers of self-actualization, and it’s not widely accepted that things like mystical experiences, creativity, and a sense of purpose are necessary for overall well-being. “It’s new territory for us as people measuring psychological effects, and it’s a challenge,” says Harriet de Wit, PhD, founder of the Human Behavioral Pharmacology Laboratory at the University of Chicago. De Wit recently ran an LSD microdosing study with healthy volunteers. She said the participants didn’t show any improvements in mood, but they did report small boosts in feelings of “oneness,” “awe,” and “connection to a higher power.” While hard to measure, there’s mounting evidence to suggest these things can improve mental health and overall happiness — and that they may be needed now more than ever. Western societies are on the brink of a loneliness epidemic, which some experts blame for the rise of suicide, and the United States does seem to be sliding further into a mass existential crisis caused by a sense of meaninglessness. This type of “garden-variety unhappiness,” as Pollan puts it, is hard to treat. Those advocating for the use of psychedelics for healthy people believe a consciousness-expanding trip could help. Brad Burge, a spokesman for the Multidisciplinary Association for Psychedelic Studies (MAPS), says that the organization believes that the mind-expanding benefits of psychedelics could “facilitate more holistic understandings of the world, and greater compassion for ourselves and for others.”

There’s another open question circling the use of psychedelics: their safety. Scientists still don’t have enough research to prove that these drugs are devoid of negative short- and long-term effects. This concern has launched a separate line of research into psychedelics for healthy people — one specifically focused on examining safety. Though de Wit’s study used healthy volunteers, one main purpose of the research was to examine the potential risks involved in microdosing LSD as a treatment for depression. (No adverse risks were found). According to Brad Burge, the Beckley Foundation, a psychedelic research and policy organization, is also currently running a safety study to see if there are any potential negative side effects of microdosing LSD (though the researchers will also take measurements around creativity). Knowing the risks associated with these drugs is a critical first step to considering a future where healthy people take psychedelics in the name of self-improvement. But it’s also foundational to psychedelics’ potential as a clinical intervention. Researchers are taking a top-down approach to advocating for the use of psychedelics: first proving the drugs’ efficacy as a treatment for mental illness, then showing that their ability to push the human mind to new realms of understanding could be beneficial to all. “Our long-term mission is to see these substances used in any setting by humans in which they can be used safely and effectively for any purpose,” says Burge. “But in order to do that, we need to work carefully and methodically to follow all the rules and regulations. That’s how we’re going to achieve the goal.”

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When it comes to psychedelic studies we’ve got a broad and diverse range of substances to study. So we’ll do our best to break down the differences in this large and expanding chemical family. Actually, when you think about psychedelics you should know that you’re at the top of the family tree. Meaning, many different chemical classes fall under the psychedelic chemical category. To be specific, you’ve got tryptamines, lysergamides and also phenethylamines which all contain chemical compounds that fall within the psychedelic family as well. Chemically, every substance that is classified a psychedelic consists of a benzene ring. But then distinct differences are found between the different sub-classes. Besides differences in chemical structure, the reported effects of psychedelics are broad and range from purely visual to a mix of visual, cognitive and hallucinatory states. So if you’re currently planning a study into psychedelics than we recommend checking out our inventory of in stock and available psychedelics below. We’ve broken down the psychedelics into categories and you can click each specific substance to find out more about it’s chemical structure and reported effect.
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